반응 #220813

반응 방정식

hydrogen peroxide

1-oxyl-2,2,6,6-tetramethylpiperid-4-one

methanesulfonic acid

cyclohexane

hydrogen peroxide

→

title compound

수율 35.0%

1-Cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-one

수율 35.0%

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONShortly after the addition
2. 2
   농축The reaction mixture is concentrated

실험 절차

A solution of 20.1 g (0.295 mol) of 50% aqueous hydrogen peroxide is added over 6 hours at 60° C. to a mixture of 8.51 g (50.0 mmol) of 1-oxyl-2,2,6,6-tetramethylpiperid-4-one, 0.70 g (2.5 mmol) of iron(II) sulfate heptahydrate, 0.3 ml (5 mmol) of methanesulfonic acid, 11 ml of cyclohexane, and 90 ml of methanol. Shortly after the addition is completed, the reaction mixture tests negative for hydrogen peroxide. The reaction mixture is concentrated to afford 4.4 g (35% yield) of the title compound, isolated as a yellow oil. Structure is confirmed by mass spectrometry and NMR analysis.

출처