반응 #220695

반응 방정식

(2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone

1,1,1-trifluoro-pentane-2,4-dione

→

2,2,2-trifluoro-1-[4-(4-fluoro-phenyl)-2-methyl-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-b]pyridin-3-yl)-ethanone

수율 14.0%

용매

acetic acid

반응 조건

후처리

1. 1
   농축concentrated in vacuo

실험 절차

To a stirred solution of 50 mg (0.19 mmol) (2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone in 2 ml acetic acid was added 0.024 ml (0.19 mmol) of 1,1,1-trifluoro-pentane-2,4-dione and one drop of sulfuric acid. The mixture was then stirred at 100° C. for 10 minutes in a microwave and then concentrated in vacuo. Flash chromatography (heptane/ethyl acetate 9:1) afforded 10 mg (14%) 2,2,2-trifluoro-1-[4-(4-fluoro-phenyl)-2-methyl-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-b]pyridin-3-yl)-ethanone as a light brown solid. ES-MS m/e (%): 380 (M+H+, 100).

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