반응 #2206792

ord-6a3a9d8a2d244dc799f2d4b94424bff6

반응 방정식

CCc1ccccc1C(=O)c1sc(NCCCNC(=O)OC(C)(C)C)nc1C
{3-[5-(2-Ethyl-benzoyl)-4-methyl-thiazol-2-ylamino]-propyl}-carbamic acid tert-butyl ester
O=S(=O)(Cl)c1cccs1
thiophene-2-sulfonyl chloride
→
CCc1ccccc1C(=O)c1sc(NCCCNS(=O)(=O)c2cccs2)nc1C
title compound
CCc1ccccc1C(=O)c1sc(NCCCNS(=O)(=O)c2cccs2)nc1C
Thiophene-2-sulfonic Acid {3-[5-(2-Ethyl-benzoyl)-4-methyl-thiazol-2-ylamino]-propyl}amide

반응물

CCc1ccccc1C(=O)c1sc(NCCCNC(=O)OC(C)(C)C)nc1C
{3-[5-(2-Ethyl-benzoyl)-4-methyl-thiazol-2-ylamino]-propyl}-carbamic acid tert-butyl ester
O=S(=O)(Cl)c1cccs1
thiophene-2-sulfonyl chloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared from {3-[5-(2-Ethyl-benzoyl)-4-methyl-thiazol-2-ylamino]-propyl}-carbamic acid tert-butyl ester and thiophene-2-sulfonyl chloride according to example BF. Off-white oil, 55%. MS (m/e): 448.1 (M+H, 100%).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06686381B2uspto-grants-2004_02