반응 #220447

반응 방정식

product

3-Azido-2,4-dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

→

3-Amino-2,4-dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

반응 조건

후처리

1. 1
   기타was prepared as a white solid
2. 2
   기타Purification
3. 3
   세척eluting with CH2Cl2/MeOH (98:2 gradient to 95:5
4. 4
   기타with 5% NH3 in the MeOH) followed by recrystallization

실험 절차

Following General Procedure 8-L using the product from Step B, 3-amino-2,4-dioxo-1,5-bis-cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared as a white solid. Purification was by flash chromatography eluting with CH2Cl2/MeOH (98:2 gradient to 95:5, with 5% NH3 in the MeOH) followed by recrystallization from warm CH2Cl2/hexanes (1:1) to −23° C.

출처