반응 #220446

반응 방정식

product

2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

(bromomethyl)cyclopropane

→

2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

반응 조건

후처리

1. 1
   기타Purification
2. 2
   세척eluting with EtOAc/hexanes (3:7 gradient to straight EtOAc)
3. 3
   기타recrystallization from EtOAc/hexanes

실험 절차

2,4-Dioxo-1,5-bis-cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared following General Procedure 8-M using the product from Example 8-P, Step A, and (bromomethyl)cyclopropane (Lancaster). Purification was by flash chromatography eluting with EtOAc/hexanes (3:7 gradient to straight EtOAc), then recrystallization from EtOAc/hexanes.

출처