반응 #220296

반응 방정식

Adenine

PMEA

adenine

ethylene carbonate

Magnesium Isopropoxide

→

9-(2-hydroxyethyl)adenine

수율 90.0%

용매

toluene

DMF

반응 조건

후처리

1. 1
   온도The reaction was cooled to below 50° C.
2. 2
   온도The slurry was further cooled to 5° C. for 2 hours
3. 3
   여과filtered
4. 4
   세척rinsed with toluene (2×)
5. 5
   기타The wet solid was dried in vacuo at 65° C.

실험 절차

Adenine to PMEA using Magnesium Isopropoxide. To a suspension of adenine (16.8 g, 0.124 mol) in DMF (41.9 ml) was added ethylene carbonate (12.1 g, 0.137 mol) and sodium hydroxide (.100 g, 0.0025 mol). The mixture was heated at 130° C. overnight. The reaction was cooled to below 50° C. and toluene (62.1 ml) was added. The slurry was further cooled to 5° C. for 2 hours, filtered, and rinsed with toluene (2×). The wet solid was dried in vacuo at 65° C. to yield 20.0 g (90%) of 9-(2-hydroxyethyl)adenine as an off-white solid. Mp: 238-240° C.

출처