반응 #220198

반응 방정식

Phenyl glyoxal

cyanoacetohydrazide

→

3-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile

용매

ethanol

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   기타the solvent was evaporated
3. 3
   기타the crude brown mixture was purified by silica chromatography (1:9 methanol/dichloromethane)
4. 4
   기타The still impure product was further recrystallized from methanol affording 70 mg pure product

실험 절차

Phenyl glyoxal (1.0 g, 7.46 mmol) and cyanoacetohydrazide (740 mg, 7.46 mmol) were heated to reflux in 10 mL ethanol for 16 hours. After cooling, the solvent was evaporated and the crude brown mixture was purified by silica chromatography (1:9 methanol/dichloromethane). The still impure product was further recrystallized from methanol affording 70 mg pure product.

출처