반응 #2201625

반응 방정식

1-(4-bromo-3-fluorophenyl)-N-methyl-2-(4-morpholinyl)ethanamine

NaHCO3

(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid

BOP reagent

triethylamine

→

N-[1-(4-bromo-3-fluorophenyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide

용매

DMF

반응 조건

후처리

1. 1
   기타The resulting precipitate was collected
2. 2
   세척washed with water
3. 3
   기타dried in vacuo
4. 4
   기타to afford an off-white solid

실험 절차

To a room temperature solution containing 1.59 g of 1-(4-bromo-3-fluorophenyl)-N-methyl-2-(4-morpholinyl)ethanamine (5.02 mmols) in 17 mL of dry DMF was added 2 g of (6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid (7.25 mmols), 2.66 g of BOP reagent (6.02 mmols), and 1.4 mL of triethylamine (10.04 mmols). The reaction mixture was stirred at ambient temperature. After 24 h 10 mL of saturated aqueous NaHCO3 was added. The resulting precipitate was collected, washed with water, and dried in vacuo to afford an off-white solid. MS (ES) m/e 574, 576 [M+H]+.

출처