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4-fluorophenylhydrazine hydrochloride

2-(3,4,5,6-tetrahydro-2H-[1,4′]bipyridin-4-yl)ethylamine

pyrazole

5-amino-1-(4-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

compound 20

5-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole

3-cyano-3-methyl-2-oxopropanoic acid ethyl ester

→

4-methyl-5-(2-chloro-benzoylamino)-1-(p-fluorophenyl)-pyrazole-3-carboxylic acid [2-(3,4,5,6-tetrahydro-2H-[1,4′]bipyridin-4-yl)-ethyl]amide

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후처리

1. 1
   기타prepared

실험 절차

The pyrazole acid, prepared as described in Procedure 8 using 5-amino-1-(4-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (prepared as described in Procedure 41 using 3-cyano-3-methyl-2-oxopropanoic acid ethyl ester (U.S. Pat. No. 4,652,669) and 4-fluorophenylhydrazine hydrochloride) in place of compound 20, was coupled to 2-(3,4,5,6-tetrahydro-2H-[1,4′]bipyridin-4-yl)ethylamine (prepared as described in Procedure 14) using the method of Procedure 10.

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