반응 #219985

ord-6dacd23111d34dacac13d12d18d78972

반응 방정식

CC1(C)OC[C@H]([C@@H](O)CN)O1
Aminoalcohol
CC1(C)OC[C@H]([C@@H](O)CN)O1
(1S)-2-amino-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol
CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
BOC2O
→
CC(C)(C)OC(=O)NC[C@H](O)[C@H]1COC(C)(C)O1
Tert-butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

반응물

CC1(C)OC[C@H]([C@@H](O)CN)O1
Aminoalcohol
CC1(C)OC[C@H]([C@@H](O)CN)O1
(1S)-2-amino-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol
CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
BOC2O

시약

없음

용매

C1CCOC1
THF

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The solvent was removed
  2. 2
    기타the product purified

실험 절차

Aminoalcohol 23 was dissolved in THF and BOC2O was added and stirred for several hrs. The solvent was removed and the product purified using silica gel chromatography.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07388118B2uspto-grants-2008_06