반응 #2199711

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diisobutylaluminum hydride

(2-amino-4-methoxy-5-methylphenyl)-(2-chlorophenyl)-methanone

4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole

5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3,7-dimethyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine

→

5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3,7-dimethyl-pyrazolo[3,4-b][1,4]benzodiazepine

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실험 절차

5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3,7-dimethyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVz) was prepared by reacting 0.0012 moles of (2-amino-4-methoxy-5-methylphenyl)-(2-chlorophenyl)-methanone (Xz) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3,7-dimethyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine (XIVz) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=353.

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