반응 #2199668

반응 방정식

(2-amino-4,5-difluorophenyl)-(2-chlorophenyl)-methanone

methanol

sodium methoxide

→

(2-amino-5-fluoro-4-methoxyphenyl)-(2-chlorophenyl)-methanone

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도to reflux under an inert atmosphere for 80 minutes
2. 2
   온도The mixture was then cooled
3. 3
   세척washed twice with brine
4. 4
   추출The ethyl acetate extract
5. 5
   건조was dried over anhydrous sodium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated under reduced pressure

실험 절차

A solution of 2.01 g (0.0075 mole) of (2-amino-4,5-difluorophenyl)-(2-chlorophenyl)-methanone (Xmm), 24 mL of methanol and 2.08 mL of 25% sodium methoxide solution was heated to reflux under an inert atmosphere for 80 minutes. The mixture was then cooled, taken up in ethyl acetate and washed twice with brine. The ethyl acetate extract was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to yield 2.04 g of aminobenzopheneone (2-amino-5-fluoro-4-methoxyphenyl)-(2-chlorophenyl)-methanone (Xa) as a crystalline yellow solid. MH+/Z=280.

출처