반응 #2199155

반응 방정식

hydrochloric acid

N-hexylbenzylamine

(3-{[2-(Methoxycarbonyl)benzyl]oxy}phenyl)acetic acid

EDC

→

Methyl 2-[(3-{2-[benzyl(hexyl)amino]-2-oxoethyl}phenoxy)methyl]benzoate

용매

water

DCM

반응 조건

후처리

1. 1
   기타The two phases were separated
2. 2
   여과Filter Tube
3. 3
   기타The obtained organic portion was evaporated in vacuum and 59 mg crude oil product
4. 4
   workup.WAITwas left

실험 절차

(3-{[2-(Methoxycarbonyl)benzyl]oxy}phenyl)acetic acid (60 mg, 0.2 mmol) was dissolved in DCM (2 ml), N-hexylbenzylamine (46 mg, 0.24 mmol) was added, then EDC (46 mg, 0.24 mmol) was added and then DMAP (29.3 mg, 0.24 mmol) was added. The mixture was stirred at room temperature overnight. 1% hydrochloric acid (1 ml) and water (1 ml) were added into the mixture. The two phases were separated by using a Whatman Filter Tube. The obtained organic portion was evaporated in vacuum and 59 mg crude oil product was left. It was then used directly in next step.

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