반응 #2197443

반응 방정식

methyl 4-{[{2-[(5-bromopentyl)oxy]phenethyl}(5-ethoxy-5-oxopentyl)amino]methyl}benzoate

N-phenylpiperazine

triethylamine

→

Methyl 4-{[(5-ethoxy-5-oxopentyl)(2-{[5-(4-phenylpiperazino)-pentyl]oxy}phenethyl)amino]methyl}benzoate

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도at reflux for 18 hours
2. 2
   세척The reaction solution is washed with water
3. 3
   농축concentrated
4. 4
   기타chromatographed over silica gel using the mobile phase ethyl acetate/methanol 10/1

실험 절차

200.0 mg (0.355 mmol) of methyl 4-{[{2-[(5-bromopentyl)oxy]phenethyl}(5-ethoxy-5-oxopentyl)amino]methyl}benzoate from Ex. 107, 69.21 mg of N-phenylpiperazine and 71.95 mg (0.711 mmol) of triethylamine in 2 ml of tetrahydrofuran are heated at reflux for 18 hours. The reaction solution is washed with water, concentrated and chromatographed over silica gel using the mobile phase ethyl acetate/methanol 10/1.

출처