반응 #219698

반응 방정식

2,2-difluoro-1,3-propandiamine dihydrochloride

guanidine hydrochloride

sodium methylate

→

5,5-Difluoro-1,4,5,6-tetrahydro-2-pyrimidinamine

반응 조건

실험 절차

A mixture of 2.95 g (16.12 mmol) of 2,2-difluoro-1,3-propandiamine dihydrochloride (Tetrahedron (1994) 50(29), 8617-8632), 1.54 g (16.12 mmol) of guanidine hydrochloride and 2.19 g (32.23 mmol) of sodium methylate was heated at 150° C. during 18 h. The cooled mixture was used as such in the subsequent step.

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