반응 #2196

반응 방정식

4-chloro-4'-methylthiomethylbenzophenone

methanol

Sodium periodate

→

desired product

수율 93.0%

4-Chloro-4'-methylsulfinylmethylbenzophenone

수율 93.0%

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONwas added to this solution
2. 2
   농축The reaction mixture was concentrated
3. 3
   workup.ADDITIONwater was added
4. 4
   추출The mixture was extracted with ethyl acetate
5. 5
   세척The ethyl acetate layer was washed with water
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
8. 8
   세척The residual solid was washed with n-hexane

실험 절차

4-chloro-4'-methylthiomethylbenzophenone (4.2 g) was added to methanol (150 ml). Sodium periodate (3.6 g) dissolved in water (20 ml), was added to this solution, and the mixture was stirred for 16 hours at room temperature. The reaction mixture was concentrated, and water was added thereto. The mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (4.1 g, melting point: 116° to 118° C., yield: 93%).

출처