반응 #2192210

반응 방정식

3′-chloro-4′-fluoroacetophenone

triethylsilane

→

Intermediate 221.1

수율 28.3%

2-chloro-4-ethyl-1-fluorobenzene

수율 28.3%

용매

TFA

반응 조건

후처리

1. 1
   농축concentrated
2. 2
   기타The crude product was purified by flash chromatography (100% hexanes, 2×)

실험 절차

To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.

출처