반응 #2192

반응 방정식

4-bromomethyl-4'-chlorobenzophenone

sodium methanesulfinate

N,N-dimethylformamide

→

desired product

수율 90.6%

4-Chloro-4'-methylsulfonylmethyl-benzophenone

수율 90.6%

용매

Water

반응 조건

후처리

1. 1
   추출the mixture was extracted with ethyl acetate
2. 2
   세척The ethyl acetate layer was washed with water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
5. 5
   세척The residual solid was washed with n-hexane

실험 절차

4-bromomethyl-4'-chlorobenzophenone (3.1 g) and sodium methanesulfinate (1.5 g) were added to N,N-dimethylformamide (50 ml), and the mixture was stirred for 16 hours at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.8 g, melting point: 164° to 166° C., yield: 90%).

출처