반응 #2186192

반응 방정식

3-Piperazin-1-yl-phenol

1-bromo-2-fluoroethane

→

desired product

수율 48.0%

3-[4-(2-Fluoro-ethyl)-piperazin-1 -yl]-phenol

수율 48.0%

용매

DMF

반응 조건

후처리

1. 1
   기타to reach room temperature
2. 2
   기타evaporated
3. 3
   기타the residue column chromatographed (silica gel, ethyl acetate/petroleum ether 9:1)

실험 절차

1 g (5.61 mmol) 3-Piperazin-1-yl-phenol and 0.5 mL (1.25 eq) 1-bromo-2-fluoroethane are stirred 20 h at 60° C. in 5 mL DMF, the reaction mixture allowed to reach room temperature and evaporated, and the residue column chromatographed (silica gel, ethyl acetate/petroleum ether 9:1) to yield 600 mg (48%) of the desired product as a brown oil.

출처