반응 #2186167

반응 방정식

acetone

sulfuric acid

L-ascorbic acid

→

5,6-O-isopropylidene-L-ascorbic acid

수율 115.4%

반응 조건

후처리

1. 1
   기타The mixture was then reacted at the temperature of the previous step for 17 hours
2. 2
   여과filtered
3. 3
   세척washed with cold acetone

실험 절차

With nitrogen substitution, 557.8 grams (9.6 moles) of acetone was cooled to −5 degrees C., 54.3 grams (0.2 moles) of 28% fuming sulfuric acid was dripped, and 176.1 grams (1.0 mole) of L-ascorbic acid was added. The mixture was then reacted at the temperature of the previous step for 17 hours, filtered and washed with cold acetone to obtain 249.5 grams of 5,6-O-isopropylidene-L-ascorbic acid (86.7% in purity) in the form of a wet cake.

출처