반응 #218556

반응 방정식

HCl

2-fluoro-nitrobenzene

2-amino-5-tert-butyl-thiophene-3-carbonitrile

NaH

→

title compound

수율 75.0%

5-tert-Butyl-2-(2-nitro-phenylamino)-thiophene-3-carbonitrile

수율 75.0%

용매

THF

THF

THF

반응 조건

후처리

1. 1
   workup.STIRRINGStir overnight
2. 2
   추출Extract the mixture with diethyl ether (400 mL)
3. 3
   세척Wash the ether layer with 2 N HCl (400 mL), brine (250 mL)
4. 4
   건조dry (Na2SO4)
5. 5
   농축concentrate
6. 6
   기타to afford
7. 7
   workup.ADDITIONa mixture of crystals in a dark oily residue
8. 8
   기타Triturate the crystals with hexanes
9. 9
   여과filter

실험 절차

Add a solution of 2-amino-5-tert-butyl-thiophene-3-carbonitrile (16.9 g, 94 mmol) in THF (50 mL) to a mixture of washed NaH (from 6.76 g of 60% mineral oil dispersion) in THF (200 mL) in a water bath at room temperature. Stir 15 minutes, then add a solution of 2-fluoro-nitrobenzene (13.2 g, 94 mmol) in THF (50 mL) dropwise. Stir overnight. Pour the purple reaction mixture unto 6 N HCl (400 mL). Extract the mixture with diethyl ether (400 mL). Wash the ether layer with 2 N HCl (400 mL), brine (250 mL), dry (Na2SO4), and concentrate to afford a mixture of crystals in a dark oily residue. Triturate the crystals with hexanes and filter to afford the title compound as a red powder (21.2 g, 75%) mp 85-90° C.: 1H NMR (CDCl3) δ 1.39 (s, 9H), 6.81 (s, 1H), 6.97 (t, 1H), 7.23 (d, 1H), 7.53 (t, 1H), 8.25 (d, 1H), 9.66 (bs, 1H).

출처