반응 #2184651

반응 방정식

4-bromo-2-cyclopropoxy-1-methoxybenzene

boron tribromide

→

title compound

수율 103.6%

4-Bromo-2-cyclopropoxyphenol

수율 103.6%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONAfter completion of the addition
2. 2
   기타After completion of the reaction
3. 3
   추출extracted with toluene
4. 4
   기타The organic layer after separation
5. 5
   세척was washed with a saturated aqueous solution of sodium chloride
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   농축concentrated under reduced pressure

실험 절차

To 300 ml of dehydrated dichloromethane solution containing 60.0 g (247 mmol) of 4-bromo-2-cyclopropoxy-1-methoxybenzene obtained in Reference Example 7-(c) was added 300 ml of dichloromethane solution containing 1M boron tribromide under argon atmosphere at −70° C. After completion of the addition, the mixture was gradually raised to 0° C., and stirred at the same temperature for 30 minutes. After completion of the reaction, the reaction mixture was poured into ice-water, and extracted with toluene. The organic layer after separation was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 58.6 g of the title compound as a blue-greenish solid substantially quantitatively.

출처