반응 #2183344

반응 방정식

{1-[4-Hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-carbamic acid tert-butyl ester

TFA

→

title compound

4-(3-Amino-azetidin-1-yl)-1-(6-methoxy-pyridin-3-yl)-cyclohexanol TFA salt

용매

DCM

반응 조건

후처리

1. 1
   기타The solvent was removed
2. 2
   기타dried under vacuum

실험 절차

{1-[4-Hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-carbamic acid tert-butyl ester (less polar isomer from Step A, 5.50 g, 14.6 mmol) in DCM (10 mL) and TFA (10 mL) at room temperature was stirred for 2 hours. The solvent was removed and dried under vacuum to give the title compound as colorless oil.

출처