반응 #218290
ord-5b1e2c6c98144fec82acbed83173a15c
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The precipitate was filtered
- 2세척washed with 10 mL of isopropanol
- 3기타dried
실험 절차
A 100-mL, 1-necked round bottom flask (with magnetic stir-bar and dry N2 adaptor) was charged with 11.6 mL (12.0 g, 100 mmol) of o-tolualdehyde, 8.8 mL (9.9 g, 100 mmol) of methyl cyanoacetate, and 50 mL of isopropanol. Morpholine (0.50 mL, 0.55 g, 6.3 mmol, 6.3 mol %) was added and the mixture was stirred at 20–33° C. for 60 minutes. This mixture was diluted with 25 mL of isopropanol. The precipitate was filtered, washed with 10 mL of isopropanol, and dried to afford 17.37 g (86.3%) of methyl 2-cyano-3-(2-mehtylphenyl)-2-propenoate as a colorless solid.