반응 #218032

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6-(4-formyl-2-methoxyphenoxy)nicotinamide

isoamylamine

→

title compound

수율 30.4%

6-{2-Methoxy-4-[(3-methylbutylamino)methyl]phenoxy}nicotinamide

수율 30.4%

반응 조건

실험 절차

Using a method similar to Example 405, a reaction of 6-(4-formyl-2-methoxyphenoxy)nicotinamide (0.0423 g, 0.155 mmol) and isoamylamine (0.020 g, 0.171 mmol) gives the title compound (0.0162 g, 30.3%): TOF MS ES+ 344.2 (M+H)+, HRMS calcd for C19H26N3O3 344.1974 (M+H)+, found 344.1949, time 0.39 min; HPLC [YMC-Pack Pro C-18 (150×4.6 mm, S-5 microm), 0.1% TFA/acetonitrile in 0.1% TFA/water at 1.0 mL/min, 20-99% over 23 min], tR=5.9 min, 100% purity.

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