반응 #217750

반응 방정식

2-cyano-2-(1-isopropyl-butyl)-succinic acid 4-tert-butyl ester 1-methyl ester

NaCl

H2O

→

3-cyano-4-isopropyl-heptanoic acid t-butyl ester

수율 75.2%

용매

DMSO

brine

반응 조건

후처리

1. 1
   온도The mixture is cooled to room temperature
2. 2
   추출The organic products are extracted into Et2O (3×50 mL)
3. 3
   세척washed with 50 mL of H2O and 50 mL of brine
4. 4
   건조Drying over Na2SO4 and evaporation of the solvent

실험 절차

A mixture of 2-cyano-2-(1-isopropyl-butyl)-succinic acid 4-tert-butyl ester 1-methyl ester (1.3 g, 4.2 mmol), NaCl (0.25 g, 4.2 mmol), and H2O (0.15 g, 8.3 mmol) in 25 mL of DMSO is warmed to 130° C. for 12 hours. The mixture is cooled to room temperature and diluted with 100 mL of brine. The organic products are extracted into Et2O (3×50 mL). The organic layers are combined and washed with 50 mL of H2O and 50 mL of brine. Drying over Na2SO4 and evaporation of the solvent gives 0.8 g (75% yield) of 3-cyano-4-isopropyl-heptanoic acid t-butyl ester as an oil.

출처