반응 #2176235

반응 방정식

N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl)methanesulfonamide

N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl)-N-(methylsulfonyl)methansulfonamide

→

N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-(methylsulfonyl)methanesulfonamide compound with N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methanesulfonamide

반응 조건

후처리

1. 1
   기타was carried on to the next step without purification

실험 절차

To a suspension of Example 226a (118 mg, 0.23 mmol) in 4 mL dichloromethane was added triethylamine (0.64 mL, 4.6 mmol). The reaction flask was cooled in an ice bath and methanesulfonyl chloride (0.054 mL, 0.69 mmol) added. After stirring 10 minutes, the ice bath was removed and the reaction mixture stirred 2 days at room temperature. The solvent was evaporated to dryness to give a crude product that was a mixture of N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl)methanesulfonamide and N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl)-N-(methylsulfonyl)methansulfonamide that was carried on to the next step without purification.

출처