반응 #217600

반응 방정식

hydrochloric acid

6-chloro-3-pyridinesulfonyl chloride

sodium hydroxide

NaOH

→

title compound

6-Chloro-3-pyridinesulfonic acid sodium salt

용매

dioxane

water

반응 조건

후처리

1. 1
   기타The material was dried on a Dean and Stark trap

실험 절차

A solution of 6-chloro-3-pyridinesulfonyl chloride (5.0 g, 24 mmol) (C. Rath. Annalen. 1931, 487, 105-119) in dioxane (10 ml) and the solution cooled to 0° C. A solution of sodium hydroxide (1.88 g, 47 mmol) in water (20 ml) was added drop-wise to the stirred solution over 10 mins. After another 10 mins 0.5 pellet of NaOH was added and after a further 15 minutes the pH was adjusted to pH 7 with 2M hydrochloric acid and the solvent was vacuumed down. The material was dried on a Dean and Stark trap to give the title compound. MS (ES−) 192/194 [M−H]−.

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