반응 #2173740

ord-075e31e24173472085198e6c93d9931c

반응 방정식

N[C@H]1CC[C@H](O)CC1
(trans)-(4-hydroxy-cyclohexyl)-amine
CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
di-tert.-butyl dicarbonate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
lithium aluminum hydride
→
CN[C@H]1CC[C@H](O)CC1
title compound
CN[C@H]1CC[C@H](O)CC1
(trans)-(4-hydroxy-cyclohexyl)-methyl-amine

반응물

N[C@H]1CC[C@H](O)CC1
(trans)-(4-hydroxy-cyclohexyl)-amine
CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
di-tert.-butyl dicarbonate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
lithium aluminum hydride

시약

없음

용매

[Na+].[OH-]
sodium hydroxide
C1CCOC1
THF

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared from (trans)-(4-hydroxy-cyclohexyl)-amine by reaction with di-tert.-butyl dicarbonate in aqueous sodium hydroxide under standard conditions and subsequent reduction with lithium aluminum hydride in THF under standard conditions.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06727247B2uspto-grants-2004_04