반응 #2171036

반응 방정식

4-bromo-2,6-difluoroaniline

benzyl bromide

potassium carbonate

→

dibenzyl(4-bromo-2,6-difluorophenyl)amine

수율 85.6%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도is refluxed for 48 hours
2. 2
   기타The mixture is subsequently evaporated in a rotary evaporator
3. 3
   workup.DISSOLUTIONthe residue is dissolved in toluene
4. 4
   추출extracted with hydrochloric acid (10%)
5. 5
   기타the toluene phase is evaporated in a rotary evaporator
6. 6
   workup.STIRRINGstirred with silica gel for about 4.5 hours
7. 7
   여과filtered with suction
8. 8
   기타evaporated in a rotary evaporator

실험 절차

A suspension of 416 g of 4-bromo-2,6-difluoroaniline, 752 g of benzyl bromide and 608 g of potassium carbonate in 2 l of acetonitrile is refluxed for 48 hours. The mixture is subsequently evaporated in a rotary evaporator, the residue is dissolved in toluene and extracted with hydrochloric acid (10%), the toluene phase is evaporated in a rotary evaporator, and the product is stirred into heptane and stirred with silica gel for about 4.5 hours, filtered with suction and evaporated in a rotary evaporator, giving dibenzyl(4-bromo-2,6-difluorophenyl)amine, yield 85.6%.

출처