반응 #217038

반응 방정식

4,5-dimethyl-1,2-phenylene diamine

ethyl pentanimidoate hydrochloride

→

expected compound

수율 74.9%

2-butyl-5,6-dimethyl-1H-benzimidazole

수율 74.9%

반응 조건

후처리

1. 1
   기타were reacted
2. 2
   기타to obtain 3.48 g of crude product which
3. 3
   기타was chromatographed on silica (eluant: methylene chloride-methanol (9-1))

실험 절차

Using the procedure of Step A of Example 1, 2.04 g of 4,5-dimethyl-1,2-phenylene diamine and 3.73 g of ethyl pentanimidoate hydrochloride [J.A.C.S., Vol. 64, p. 1827 (1942)] were reacted to obtain 3.48 g of crude product which was chromatographed on silica (eluant: methylene chloride-methanol (9-1)) to obtain 2.27 g of the expected compound melting at 110° C. An analytical sample was prepared by crystallization of 120 mg of the product from isopropyl ether to obtain 88 mg of product melting at 110° C.

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