반응 #216882

ord-3dd5b57095734c00b7e84528b23e2ce3

반응 방정식

COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1.Cl
diltiazem HCl
O=C(O)/C=C/C(=O)O
fumaric acid
O=[Si]=O
silicon dioxide
COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1.Cl
diltiazem HCl
→
COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1
DILTIAZEM

반응물

—
talc
COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1.Cl
diltiazem HCl
O=C(O)/C=C/C(=O)O
fumaric acid
O=[Si]=O
silicon dioxide
COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1.Cl
diltiazem HCl

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The mixture is dry blended for 15 minutes
  2. 2
    기타milled through a 0.013 inch screen

실험 절차

To an 80 cubic foot blender is charged 188.0 kg of diltiazem HCl, 94.0 kg of fumaric acid NF, 94.0 kg of talc, 2.8 kg of silicon dioxide, and an additional 188.0 kg of diltiazem HCl. The mixture is dry blended for 15 minutes and then milled through a 0.013 inch screen using a conventional milling machine to a sufficiently fine particle size, averaging about 75 microns.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05470584uspto-grants-1995_11