반응 #216626

반응 방정식

ethanol

water

9H-indeno[1,2-b]pyrazine-3,9(4H)-dione

p-toluenesulfonic acid

→

title compound

수율 83.0%

9H-Indeno[1,2-b]pyrazine-3,9(4H)-dione 9-ethylene acetal

수율 83.0%

용매

ethylene glycol

toluene

반응 조건

후처리

1. 1
   여과the precipitate was filtered off
2. 2
   세척washed with ethanol
3. 3
   기타dried

실험 절차

A suspension of 9H-indeno[1,2-b]pyrazine-3,9(4H)-dione (1.0 g, 5.05 mmol) in ethylene glycol (10 ml), toluene (20 ml) and p-toluenesulfonic acid (20 mg) was refluxed with water separation for 18 hours. The reaction mixture was cooled to room temperature, ethanol (5 ml) was added and the precipitate was filtered off and washed with ethanol and dried to give 1.014 g (83%) of the title compound. M.p. 296°-298° C. 1H-NMR (DMSO-d6, δ): 4.3-4.42 (m, 4H), 7.43-7.6 (m, 3H), 7.75 (d, 1H), 7.88 (s, 1H), 12.7 (s, 1H).

출처