반응 #2161261

반응 방정식

2,4,6-trichloropyrimidine

diethylamine

triethylamine

→

(2,6-Dichloro-pyrimidin-4-yl)-diethyl-amine

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   농축The mixture was then concentrated
2. 2
   workup.ADDITION25 mL of CH2Cl2 and 25 mL of water were added
3. 3
   기타The organic layer was separated
4. 4
   추출the aqueous layer was extracted by additional amount of dichloromethane (2×10 mL)
5. 5
   건조dried over anhydrous Na2SO4
6. 6
   농축concentrated
7. 7
   기타Column chromatography on silica gel afforded 1.48 g (62%) of L as colorless solid

실험 절차

To a stirred solution of 2.0 g (10.90 mmols) of 2,4,6-trichloropyrimidine in 25 mL of anhydrous ethanol at 0° C., was added drop wise a solution 0.79 g (10.90 mmols) of diethylamine in 5 mL of ethanol. This was followed by the addition of 2.3 mL (16.35 mmols) of triethylamine and the mixture was stirred for further 30 min. The mixture was then concentrated and 25 mL of CH2Cl2 and 25 mL of water were added. The organic layer was separated and the aqueous layer was extracted by additional amount of dichloromethane (2×10 mL) and the extracts were combined, dried over anhydrous Na2SO4 and concentrated. Column chromatography on silica gel afforded 1.48 g (62%) of L as colorless solid.

출처