반응 #2161258

반응 방정식

1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine

hydrogen chloride

→

1-(5-Methylpyridin-2-yl)piperazine

용매

dioxane

dioxane

반응 조건

후처리

1. 1
   농축The mixture is then concentrated
2. 2
   추출extracted several times with dichloromethane
3. 3
   건조The combined organic phases are dried over sodium sulfate
4. 4
   농축concentrated
5. 5
   기타dried in vacuo

실험 절차

3.47 g (12.5 mmol) of 1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine are dissolved in 10 ml of dioxane, and 31 ml (125 mmol) of hydrogen chloride in dioxane (4 molar) are added. The mixture is stirred at RT for 2 h. The mixture is then concentrated and the residue is rendered alkaline using a 1M aqueous sodium hydroxide solution and extracted several times with dichloromethane. The combined organic phases are dried over sodium sulfate, concentrated and dried in vacuo.

출처