반응 #2161255

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4-(trifluoromethoxy)phenyl isocyanate

ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

용매

THF

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후처리

1. 1
   기타synthesis in analogy to Example 4A step 3
2. 2
   여과The reaction mixture is filtered
3. 3
   농축the filtrate is concentrated in vacuo
4. 4
   기타purified chromatographically

실험 절차

Under argon, 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate are added to 1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis in analogy to Example 4A step 3, or also according to Tetrahedron Lett. 2003, 44, 1607 and the literature cited therein) in 50 ml of THF, and the mixture is stirred at room temperature overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo and purified chromatographically.

출처