반응 #2161253

반응 방정식

cyclohexane ethyl acetate

potassium carbonate

iodomethane

ethyl 4-nitro-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

용매

acetone

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   여과the mixture is filtered
3. 3
   세척the residue is washed with dichloromethane
4. 4
   기타The solid obtained
5. 5
   기타is dried in vacuo

실험 절차

6.80 g (36.7 mmol) of ethyl 4-nitro-1H-imidazole-2-carboxylate are dissolved in 140 ml of acetone, and 11.2 g (80.8 mmol) of potassium carbonate and 4.57 ml (73.5 mmol) of iodomethane are added. The mixture is then stirred at 60° C. for 4 h. According to TLC (cyclohexane/ethyl acetate 2:1), the starting material has been converted completely. After cooling, the mixture is filtered, the residue is washed with dichloromethane and the filtrate is freed from the solvent. The solid obtained is dried in vacuo.

출처