반응 #2161249

반응 방정식

ethyl imidazole-2-carboxylate

nitric acid

→

Ethyl 4-nitro-1H-imidazole-2-carboxylate

용매

반응 조건

후처리

1. 1
   온도after cooling
2. 2
   여과The precipitated crystals are collected by suction filtration
3. 3
   세척washed with 1500 ml of ice-water

실험 절차

While cooling on ice, 16.08 g (114.7 mmol) of ethyl imidazole-2-carboxylate are dissolved in 71.7 ml of concentrated sulpfuric acid. 71.7 ml of 100% fuming nitric acid are then added dropwise. The reaction solution is stirred at 50 to 60° C. for 3 h and, after cooling, poured onto 800 ml of an ice/water mixture. The precipitated crystals are collected by suction filtration and washed with 1500 ml of ice-water.

출처