반응 #2161248

반응 방정식

ammonium formate

ethyl 1-benzyl-1H-imidazole-2-carboxylate

ammonium formate

→

Ethyl imidazole-2-carboxylate

용매

ethanol

반응 조건

후처리

1. 1
   온도The reaction mixture is heated
2. 2
   온도under reflux for about 6 h
3. 3
   온도After cooling
4. 4
   여과the catalyst is filtered off
5. 5
   농축the filtrate is concentrated in vacuo
6. 6
   기타The product that crystallizes out during this operation
7. 7
   기타is triturated with 80 ml of ice-water
8. 8
   여과collected by suction filtration

실험 절차

34.7 g (150.9 mmol) of ethyl 1-benzyl-1H-imidazole-2-carboxylate are dissolved in 1005 ml of ethanol, and 34 g of ammonium formate are added. The reaction mixture is heated under reflux for about 6 h. A total of 8 g of 10% palladium-on-carbon and 18 g of ammonium formate are thereby added in small portions. After cooling, the catalyst is filtered off and the filtrate is concentrated in vacuo. The product that crystallizes out during this operation is triturated with 80 ml of ice-water and collected by suction filtration.

출처