반응 #215917

반응 방정식

4-hydroxy-3-methoxybenzaldehyde

hydantoin

β-alanine

acetic acid

→

product

수율 42.7%

5- [(4-Hydroxy-3-methoxyphenyl )methylene ]-2,4-imidazolidinedione

수율 42.7%

용매

water

반응 조건

후처리

1. 1
   온도heated to reflux
2. 2
   여과the precipitate is filtered off
3. 3
   세척rinsed successively with water (3X), ethanol (2X), and ether (2X)
4. 4
   기타dried
5. 5
   기타Recrystallization from methanol

실험 절차

A mixture of 4-hydroxy-3-methoxybenzaldehyde (4.6 g, 30 mmoles), hydantoin (3.0 g, 30 mmoles), β-alanine (1.4 g, 16 mmoles), and acetic acid (40 ml) is stirred under an inert atmosphere and heated to reflux. After 4 hours the mixture is stirred into water (350 ml) and the precipitate is filtered off, rinsed successively with water (3X), ethanol (2X), and ether (2X), and dried. Recrystallization from methanol afforded the pure product (3.0 g), mp 272°-273° C.

출처