반응 #2158998

반응 방정식

thiol

1-(2-sulfoethyl)tetrazole-5-thiol

isopropanol

cyclohexylamine

acetonitrile

→

1-(2-sulfoethyl)tetrazole-5-thiol

di-cyclohexylamine

반응 조건

후처리

1. 1
   workup.ADDITIONwas added

실험 절차

A mixture of 21.5 g. (0.087 mol.) of methyl 2-sulfoethyldithiocarbamate potassium salt (0.5 hydrate) and 7.16 g. (0.11 mol.) of sodium azide in 200 ml. of water was refluxed for two hours. The solution was cooled to 25° and extracted with ethyl acetate. The aqueous phase was treated with Amberlite IR-120H resin, washed with ether and evaporated to give an oil. The oil was dissolved in acetone, the solution was filtered and the filtrate was evaporated to dryness to give 1-(2-sulfoethyl)tetrazole-5-thiol. The thiol was dissolved in isopropanol, cyclohexylamine was added until pH 8-9 and acetonitrile was added to give 1-(2-sulfoethyl)tetrazole-5-thiol as the di-cyclohexylamine salt.

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