반응 #215888

반응 방정식

3-carbomethoxytetrahydrothiophene-4-one

triethylamine

diphenylchlorophosphate

→

oil

수율 108.1%

4-[(Diphenoxyphosphinyl)oxy]-2,5-dihydro-3-thiophenecarboxylic acid methyl ester

수율 108.1%

용매

THF

반응 조건

후처리

1. 1
   workup.ADDITIONtreated with ice-cold water
2. 2
   추출extracted with diethyl ether
3. 3
   세척The extracts were washed with saturated NaHCO3, brine
4. 4
   건조dried with Na2SO4
5. 5
   기타evaporated

실험 절차

To a solution of 3-carbomethoxytetrahydrothiophene-4-one (Gianturco M. A., Friedel P., Giammarino A. S., Tetrahedron, 20:1772 (1964)) (4.0 g, 25 mmol) and triethylamine (6.6 g, 65 mmol) in 50 mL dry THF at 0° was added, over a 15 minute period, diphenylchlorophosphate (17.5 g, 65 mmol). The reaction mixture was stirred at room temperature for 2 days, then treated with ice-cold water and extracted with diethyl ether. The extracts were washed with saturated NaHCO3, brine, dried with Na2SO4, and evaporated to yield an oil (10.6 g).

출처