반응 #215846

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4-(3-thienyl)-3-butenoic acid

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide

8-chlorodibenz[b,f][1,41oxazepine-10(11H)-carboxylic acid, hydrazide

→

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3E-butenyl]hydrazide

8-chlorodibenz[b,f][1,4 ]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3Z-butenyl]hydrazide

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후처리

1. 1
   기타prepared
2. 2
   기타prepared
3. 3
   기타to yield 33% trans and 14%
4. 4
   기타after separation by column chromatography

실험 절차

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3E-butenyl]hydrazide (trans) (30) and 8-chlorodibenz[b,f][1,4 ]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3Z-butenyl]hydrazide (cis) (31) were prepared in the manner described in Example 7 on a 5.2 mmol scale from 4-(3-thienyl)-3-butenoic acid (29), prepared as described above in Example 29, and 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide (1), prepared as described above in Example 1, to yield 33% trans and 14% cis products after separation by column chromatography.

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