반응 #215802

반응 방정식

sodium hydroxide

N,N-Diethyl-2-(4-nitrophenoxy)ethylamine

hydrochloric acid

→

4-[2-(N,N-diethylamino)ethoxy]aniline

용매

water

—

IMS

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   온도under reflux for 7 hours
3. 3
   기타evaporated under reduced pressure
4. 4
   기타The residue was partitioned between water and ether
5. 5
   기타The organic layer was separated
6. 6
   기타dried
7. 7
   기타evaporated

실험 절차

N,N-Diethyl-2-(4-nitrophenoxy)ethylamine (4.0 g) (prepared by the method described in Helv. Chim. Acta. 1960, 43, 1971) was dissolved in IMS (70 ml), water (10 ml) and concentrated hydrochloric acid (2 ml). The mixture was boiled under reflux and then reduced iron powder (4.6 g) was carefully added in portions. The mixture was boiled under reflux for 7 hours then hot filtered. The filtrate was basified with 5M sodium hydroxide solution and then evaporated under reduced pressure. The residue was partitioned between water and ether. The organic layer was separated, dried and evaporated to give 4-[2-(N,N-diethylamino)ethoxy]aniline as an oil.

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