반응 #215787

반응 방정식

6-trifluoromethylpyridin-2-amine

diethyl ethoxymethylenemalonate

→

diethyl 2-(6-trifluoromethyl-2-pyridylaminomethylene)malonate

용매

반응 조건

후처리

1. 1
   온도The mixture was cooled
2. 2
   여과The mixture was filtered
3. 3
   기타the residue was recrystallised from IMS

실험 절차

A mixture of 6-trifluoromethylpyridin-2-amine (17.2 g) and diethyl ethoxymethylenemalonate (22.9 g) was heated at 95° C., under vacuum for 8 hours. The mixture was cooled and diluted with petroleum ether b.p. 60°-80° C. (50 ml). The mixture was filtered and the residue was recrystallised from IMS to give diethyl 2-(6-trifluoromethyl-2-pyridylaminomethylene)malonate, m.p. 125°-128° C.

출처