반응 #215709

반응 방정식

ethyl 2-(2,5-dichloro-3,4,6-trifluorobenzoyl)-3-cyclopropylamino-acrylate

sodium fluoride

water

→

Ethyl 5,8-dichloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

용매

N-methyl-2-pyrrolidone

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   기타The solid which has precipitated
3. 3
   여과is filtered off with suction
4. 4
   세척washed with water
5. 5
   기타dried at 80° C. in a drying cabinet

실험 절차

19.1 g (0.05 mol) of ethyl 2-(2,5-dichloro-3,4,6-trifluorobenzoyl)-3-cyclopropylamino-acrylate are heated at 160°-170° C. together with 4.2 g (0.1 mol) of sodium fluoride in 100 ml of N-methyl-2-pyrrolidone for 5 hours. After cooling, the mixture is poured onto 200 ml of water. The solid which has precipitated is filtered off with suction, washed with water and dried at 80° C. in a drying cabinet.

출처