반응 #215580

반응 방정식

2,3-dicyano-5,6-dichloropyrazine

Isopropanol

→

2,3-dicyano-5-chloro-6-isopropoxypyrazine

수율 45.0%

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 10 hours
2. 2
   기타After the reaction
3. 3
   workup.DISTILLATIONthe isopropanol was distilled off under reduced pressure
4. 4
   기타The crude product obtained (1.14 g)
5. 5
   기타was chromatographed on a column of silica gel

실험 절차

Isopropanol (50 ml) was added to 1.99 g (0.01 mole) of 2,3-dicyano-5,6-dichloropyrazine, and the mixture was refluxed for 10 hours. After the reaction, the isopropanol was distilled off under reduced pressure. The crude product obtained (1.14 g) was chromatographed on a column of silica gel using benzene-n-hexane as an eluent to afford 1.00 g (yield 45%) of 2,3-dicyano-5-chloro-6-isopropoxypyrazine.

출처