반응 #215519

반응 방정식

4-(2-cyclohexylethylamino)phenylacetic acid

lactic acid

toluenesulfonic acid

→

1-carboxyethyl 4-(2-cyclohexylethylamino)-phenylacetate

용매

toluene

반응 조건

후처리

1. 1
   workup.ADDITIONA flask containing 10.0 g
2. 2
   workup.ADDITIONcharged
3. 3
   온도The solution is refluxed for 24 hours during which time the Soxhlet extractor
4. 4
   workup.ADDITIONis charged twice more with fresh sieves
5. 5
   여과The hot solution is filtered
6. 6
   workup.WAITleft
7. 7
   온도to cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

실험 절차

A flask containing 10.0 g. 4-(2-cyclohexylethylamino)phenylacetic acid, 3.3 g. lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 24 hours during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate separates as off-white crystals.

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