반응 #2155154

반응 방정식

1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid [(S)-1-(3-trifluoromethyl-phenyl)-hex-5-enyl]-amide

ozone

→

1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid [(S)-5-oxo-1-(3-trifluoromethyl-phenyl)-pentyl]-amide

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타by bubbling for 30 min until a blue color
2. 2
   workup.ADDITIONdimethylsulfide (10 mL) is added
3. 3
   온도The reaction mixture is warmed to room temperature
4. 4
   농축concentrated in vacuo

실험 절차

A solution of 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid [(S)-1-(3-trifluoromethyl-phenyl)-hex-5-enyl]-amide (800 mg, 1.7 mmol) in CH2Cl2 (25 mL) at −78° C. is treated with ozone gas by bubbling for 30 min until a blue color is sustained. After stirring for an additional hour at −78° C., dimethylsulfide (10 mL) is added. The reaction mixture is warmed to room temperature and concentrated in vacuo to afford 1-(4-chloro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid [(S)-5-oxo-1-(3-trifluoromethyl-phenyl)-pentyl]-amide which is used without further purification.

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