반응 #215192

반응 방정식

1,3-diaminopropane

benzoic acid methyl ester

→

2-phenyl-tetrahydropyrimidine

수율 79.0%

반응 조건

후처리

1. 1
   workup.DISTILLATIONthe excess of diamine was distilled off

실험 절차

With 185 g 1,3-diaminopropane, 136 g benzoic acid methyl ester were reacted under pressure at 200° C. in the reactor. After 3 hours, the excess of diamine was distilled off, and the 2-phenyl-tetrahydropyrimidine was isolated in a 79% yield. Boiling point 165° C./1 mm; melting point=86°-87° C.

출처